Renal Biopsy in Paediatric Population

OBJECTIVE: To find out the pattern of glomerulopathies in paediatric population, undergoing renal biopsy at Khyber Teaching Hospital, Peshawar. METHODS: This was a prospective study carried out at the department of Nephrology at Khyber Teaching Hospital, Peshawar from June 2010 till June 2012. Ultrasound guided percutaneous renal biopsies were carried out in patients with the finding of; 1) Nephrotic range proteinuria in children. 2) Non-Nephrotic range proteinuria with evidence of hypertension / haematuria / deranged renal function or active sediments on urine microscopy. 3) Steroid resistant nephrotic syndrome in children (patients not responding to steroid in eight weeks time) and 4) Children with nephrotic syndrome who were not tolerant of steroid therapy or were considered for immunosuppressive drugs. RESULT: A total of 155 renal biopsies were done. Out of these 90 were male patients and 65 were females. The most common histopathological lesion among children population was minimal change disease (42.66%) followed by focal segmental glomerulosclerosis (25.33%) and membranous GN (16.0%). We observed that nephrotic range proteinuria was most prevalent in minimal change disease and membranous GN followed by focal segmental glomerulosclerosis. While non-nephrotic range proteinuria was mostly seen in patients with membranoprolifirative GN. CONCLUSION: In paediatric population, minimal change disease is the most common encountered glomerulopathy, followed by focal segmental glomerulosclerosis and membranous GN.